Infertilità / Myo-Inositolo

Myo-inositol in a new pharmaceutical form: a step forward to a broader clinical use

 

Objective: Dose-dependent side effects related to myo-inositol (MI) oral administration represent a significant shortcoming for its clinical use. Aiming to search for a pharmaceutical form able to be better absorbed, the pharmacokinetic (PK) profile of the new manufactured MI soft gelatin capsule form was evaluated and compared with the commercially available MI powder.

More

Myo-Inositolo / Pubblicazioni

Myo-inositol in the treatment of premenstrual dysphoric disorder

Objective Premenstrual dysphoric disorder (PMDD) is a mood disorder disrupting social and/or occupational life of affected women. Premenstrual dysphoric disorder etiology is unknown, although a pivotal role is played by the serotoninergic system. Indeed, one of the most effective treatments is selective serotonin reuptake inhibitors. Several studies have proposed a selective serotonin reuptake …

More
Infertilità / Myo-Inositolo

Inositol safety clinical evidences

Myo-inositol is a six carbon cyclitol that contains five equatorial and one axial hydroxyl groups. Myo-inositol has been classified as an insulin sensitizing agent and it is commonly used in the treatment of the Polycystic Ovary Syndrome (PCOS). However, despite its wide clinical use, there is still scarce information on the myo-inositol safety …

More
Infertilità / Myo-Inositolo

The D-chiro-inositol paradox in the ovary

The D-chiro-inositol–to–myo-inositol ratio is regulated by an insulin-dependent epimerase. Enzyme activity varies among tissues, likely owing to the specific needs of the two different molecules. We hypothesize that in the ovaries of polycystic ovary syndrome patients, epimerase activity is enhanced, leading to a local myo-inositol deficiency which in turn is responsible for the poor oocyte …

More
Myo-Inositolo / Pubblicazioni

Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality

Objective: Polycystic ovary syndrome (PCOS) is the most common cause of infertility due to menstrual dysfunction, and the most promising treatments for this disease are insulin sensitising agents. Myo-inositol and D-chiro-inositol are insulin sensitizing agents used in PCOS treatment. In the present paper, we aimed to compare the effects myo-inositol and D-chiro-inositol on …

More
Myo-Inositolo / Pubblicazioni

The effect of a combination therapy with myo-inositol and a combined oral contraceptive pill versus a combined oral contraceptive pill alone on metabolic, endocrine, and clinical parameters in polycystic ovary syndrome

Aim. Compare the effects of a combined contraceptive pill (OCP) in combination with myo-inositol (MI) on endocrine, metabolic, and clinical parameters in patients with polycystic ovary syndrome (PCOS).

Methods. One hundred fifty-five patients with PCOS were enrolled in this prospective, open-label clinical study. Patients were assigned to receive oral treatment with OCP alone (estradiol (EE) 30 …

More
Pubblicazioni

Inositol activity in oligoasthenoteratospermia – An in vitro study

Background: Oligoasthenoteratospermia, a reduction in motilty and number of spermatozoa and a change in their morphology, is one of the most relevant causes of infertility in men. One of the factors, which may influence male infertility is linked to the production of reactive oxygen species (ROS) by morphologically altered spermatozoa. Spermatozoa …

More
Pubblicazioni

Inositol activity in oligoasthenoteratospermia An in vitro study

Background: Oligoasthenoteratospermia, a reduction in motilty and number of spermatozoa and a change in their morphology, is one of the most relevant causes of infertility in men. One of the factors, which may influence male infertility is linked to the production of reactive oxygen species (ROS) by morphologically altered spermatozoa. Spermatozoa are more …

More
Pubblicazioni

Il Myo-Inositolo nella pratica clinica ostetrica-ginecologica

E’ sempre motivo di soddisfazione leggere in anteprima una monografia scienti­fica per poi presentarla all”attenzione della comunità scientifica. E’ una soddisfa­zione ancora maggiore se a redigerla sono quattro illustri esperti sull’argomento: Enrico Papaleo e Vittorio Unfer, con i quali ho stretti rapporti di amicizia e stima, e Jean-Patrice Baillargeon e Chiu Tak Yu, …

More