Infertilità / Myo-Inositolo

The Rationale of the Myo-Inositol and D-Chiro-Inositol Combined Treatment

PCOS is one of the most common endocrine disorders affecting women and it is characterized by a combination of hyper-androgenism, chronic anovulation, and insulin resistance. While a significant progress has recently been made in the diagnosis for PCOS, the optimal infertility treatment remains to be determined. Two inositol isomers, myo-inositol (MI) and D-chiro-inositol …

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Peripheral neuropathy in obstetrics: efficacy and safety of α-lipoic acid supplementation

OBJECTIVE: Neuropathic pain during pregnancy is a common condition due to the physical changes and compression around pregnancy and childbirth that make pregnant women more prone to develop several medical conditions such as carpal tunnel syndrome, sciatica, meralgia paraesthetica and other nerve entrapment syndromes. Most of the treatments usually performed to counteract neuropathic pain are …

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Inositoli: storia e personaggi di una terapia efficace

La storia dell’inositolo è una storia complessa: nel 1850 Johanes Joseph Scherer isolò dal mu­scolo un esaidrocicloesano a cui diede il nome di inositolo 1 (dal greco inos= muscolo). La struttu­ra del cicloesano permette la formazione di nove diversi stereoisomeri. Tra essi, ii myo-inositolo è l’isomero di gran lunga più distribuito in natura …

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Infertilità / Myo-Inositolo

Updates on the myo-inositol plus D-chiro-inositol combined therapy in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age. It is characterized by chronic anovulation, hyperandrogenism, and insulin resistance. It is the main cause of infertility due to the menstrual dysfunction and metabolic disorders. Women with PCOS also have an increased cardiovascular risk because of dyslipidemia and …

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Myo-inositol ovarian stimulation and IVF outcomes

OBJECTIVE: More than 60% of in vitro fertilization (IVF) cycles do not result in pregnancy. Several studies have been carried out in order to identify factors affecting the IVF outcome. The main factors influencing IVF outcome are oocyte and embryo quality. Indeed, the only way to improve IVF success rate is toimprove oocyte …

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Infertilità / Myo-Inositolo

Hereditay hemorragic teleangectasia and pregnancy

We report an uncommon case of a 38-years-old pregnant woman affected by HHT (Hereditary haemorrhagic telangiectasia; OslerWeber-Rendu syndrome) who underwent to a caesarean section (CS) without any complication. The patient at 36th weeks+1 day pregnancy referred to the Emergency Obstetric Unit due to a intercostals pain on left side. On third day after …

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Efficacy and safety of 17a-hydroxyprogesterone caproate in hormone replacement therapy

The aim of the present study was to evaluate the efficacy (in terms of induction of uterine bleeding) and safety (in terms of absence of endometrial hyperplasia) of 17a-hydroxyprogesterone caproate (17a-HPC) in a therapeutic regimen for hormonal replacement after menopause. Fifty postmenopausal patients received hormone replacement therapy (HRT) for 24 weeks. The treatment …

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Infertilità / Myo-Inositolo

Myo-inositol in a new pharmaceutical form: a step forward to a broader clinical use

Objective: Dose-dependent side effects related to myo-inositol (MI) oral administration represent a significant shortcoming for its clinical use. Aiming to search for a pharmaceutical form able to be better absorbed, the pharmacokinetic (PK) profile of the new manufactured MI soft gelatin capsule form was evaluated and compared with the commercially available MI powder.
Research design and methods: A …

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