INSUFFICIENZA DELLA FASE LUTEALE
L’ insufficienza del corpo luteo e la conseguente incapacita riproduttiva e stata ipotizzata da Jones (Jones, 1976). In seguito sono state riportate stime notevolmente differenti della presenza di questa sindrome nell’aborto ricorrente. Le prime stime variavano dal 20 al 60% (Doody and Carr, 1991) ma altri Autori hanno riportato percentuali …
Inositol metabolism is severely impaired in follicles obtained from cystic ovaries, leading to deregulated insulin transduction and steroid synthesis. On the contrary, inositol administration to women suffering from polycystic ovary syndrome (PCOS) has been proven to efficiently counteract most of the clinical hallmarks displayed by PCOS patients, including insulin resistance, hyperandrogenism and oligo-amenorrhea. We …
MoreIn the last few decades, the use of ovarian stimulation with follicle stimulating hormone (FSH) or clomiphene citrate (CC) increases the percentage of multiple pregnancies. The presence of many follicles can lead to the risk of higher-order multiple pregnancy and ovarian high stimulation syndrome (OHSS).
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MoreMetabolic syndrome (MS) is a combination of disorders characterized by alterations in carbohydrate metabolism, obesity, systemic arterial hypertension and dyslipidemia, which increase the risk of developing cardiovascular disease and diabetes. Metabolic disorders affect reproductive function controlled by the hypothalamus and the pituitary. A clinical example of such an interaction is represented by Polycystic …
MoreSecond trimester amniotic fluid myo-inositol concentrations in women later developing gestational diabetes mellitus or pregnancy-induced hypertension:
Objective: To evaluate myo-inositol concentrations in amniotic fluid in women later developing gestational diabetes and hypertension.
Methods: A retrospective study was carried out with three groups of amniotic fluid samples (15–18 gestational weeks): 30 gestational hypertension pregnancies, 30 gestational diabetes pregnancies, …
MoreMyo-inositol is a six carbon cyclitol that contains five equatorial and one axial hydroxyl groups. Myo-inositol has been classified as an insulin sensitizing agent and it is commonly used in the treatment of the Polycystic Ovary Syndrome (PCOS). However, despite its wide clinical use, there is still scarce information on the myo-inositol safety …
MoreIn polycystic ovary syndrome (PCOS) pathogenesis, both the insulin resistance and the related compensatory hyperinsulinemia are involved. Despite their similarities, Myo-inositol (MI) and D-chiro-inositol (DCI) play different roles in PCOS etiology and therapy. Indeed, in tissue such as the liver both molecules are involved in the insulin signaling, i.e. MI promotes glucose uptake …
MoreA substantial body of research on mammalian gametogenesis and human reproduction has recently investigated the effect of myo-inositol (MyoIns) on oocyte and sperm cell quality, due to its possible application to medically assisted reproduction. With a growing number of both clinical and basic research papers, the meaning of several observations now needs to …
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Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age.
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Myo-inositol is involved in metabolic changes that characterize Down syndrome
This study shows that Down syndrome metabolic changes occur very early in the fetal life, with amniotic fluid myo-inositol concentrations increasing since the mid-trimester. A possible clinical use of this finding maybe interesting
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