Pubblicazioni

Does myo-inositol effect on PCOS follicles involve cytoskeleton regulation?

Inositol metabolism is severely impaired in follicles obtained from cystic ovaries, leading to deregulated insulin transduction and steroid synthesis. On the contrary, inositol administration to women suffering from polycystic ovary syndrome (PCOS) has been proven to efficiently counteract most of the clinical hallmarks displayed by PCOS patients, including insulin resistance, hyperandrogenism and oligo-amenorrhea. We …

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Results from the International Consensus Conference on Myo-inositol and D-chiro-inositol in Obstetrics and Gynecology: the link between metabolic syndrome and PCOS

Metabolic syndrome (MS) is a combination of disorders characterized by alterations in carbohydrate metabolism, obesity, systemic arterial hypertension and dyslipidemia, which increase the risk of developing cardiovascular disease and diabetes. Metabolic disorders affect reproductive function controlled by the hypothalamus and the pituitary. A clinical example of such an interaction is represented by Polycystic …

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Pubblicazioni

Second trimester amniotic fluid myo-inositol concentrations in women

Second trimester amniotic fluid myo-inositol concentrations in women later developing gestational diabetes mellitus or pregnancy-induced hypertension:

Objective: To evaluate myo-inositol concentrations in amniotic fluid in women later developing gestational diabetes and hypertension.

Methods: A retrospective study was carried out with three groups of amniotic fluid samples (15–18 gestational weeks): 30 gestational hypertension pregnancies, 30 gestational diabetes pregnancies, …

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Infertilità / Myo-Inositolo

Inositol safety clinical evidences

Myo-inositol is a six carbon cyclitol that contains five equatorial and one axial hydroxyl groups. Myo-inositol has been classified as an insulin sensitizing agent and it is commonly used in the treatment of the Polycystic Ovary Syndrome (PCOS). However, despite its wide clinical use, there is still scarce information on the myo-inositol safety …

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Infertilità / Myo-Inositolo

Reflections on inositol(s) for PCOS therapy (Nestler-Unfer 2015)

In polycystic ovary syndrome (PCOS) pathogenesis, both the insulin resistance and the related compensatory hyperinsulinemia are involved. Despite their similarities, Myo-inositol (MI) and D-chiro-inositol (DCI) play different roles in PCOS etiology and therapy. Indeed, in tissue such as the liver both molecules are involved in the insulin signaling, i.e. MI promotes glucose uptake …

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Pubblicazioni

Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology – assisted reproduction technology

A substantial body of research on mammalian gametogenesis and human reproduction has recently investigated the effect of myo-inositol (MyoIns) on oocyte and sperm cell quality, due    to its possible application to medically assisted reproduction. With a growing number of both clinical and basic research papers, the meaning of several observations now needs to …

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Pubblicazioni

Myo-inositol in Down syndrome amniotic fluid. A case-control study.

 

Myo-inositol is involved in metabolic changes that characterize Down syndrome

This study shows that Down syndrome metabolic changes occur very early in the fetal life, with amniotic fluid myo-inositol concentrations increasing since the mid-trimester. A possible clinical use of this finding maybe interesting

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